Isaac Newton was born in a stone farmhouse in 1642, fatherless and unwanted by his mother. When he died in London in 1727 he was so renowned he was given a state funeral—an unheard-of honor for a subject whose achievements were in the realm of the intellect. During the years he was an irascible presence at Trinity College, Cambridge, Newton imagined properties of nature and gave them names—mass, gravity, velocity—things our science now takes for granted. Inspired by Aristotle, spurred on by Galileo’s discoveries and the philosophy of Descartes, Newton grasped the intangible and dared to take its measure, a leap of the mind unparalleled in his generation.