Now that Mac and Kelly Radner have a second baby on the way, they are ready to make the final move into adulthood: the suburbs. But just as they thought they'd reclaimed the neighborhood and were safe to sell, they learn that the new occupants next door are a sorority even more out of control than Teddy and his brothers. Now forced to turn to the one ex-neighbor with the skills to bring down the new Greeks next door, they bring in charismatic Teddy as their secret weapon.