For decades, ever since the war, Number One Main Street, Ballybucklebo, has housed Doctor O'Reilly and his practice. In recent years, it has also opened its doors to O'Reilly's wife, Barry Laverty, and a new addition to the practice, Doctor Nonie Stevens, a sultry and occasionally prickly young woman who may not be fitting in as well as she should. It is to Number One that patients young and old come when they need a doctor's care, for everything from the measles to a rare and baffling blood disease. Now, an unexpected turn of events threatens to drive O'Reilly from his home for good, unless the entire village can rally behind their doctor and prove that love really can conquer all.