Yorick Brown, an unemployed and unmotivated slacker who discovers he is the only male left in the world after a plague of unknown origin instantly kills every mammal with a Y chromosome. Accompanied by his mischievous monkey, Ampersand, and the mysterious Agent 355, Yorick embarks on a transcontinental journey to find his long-lost girlfriend and discover why he is the last man on earth. Yorick Brown's long journey through an Earth populated only by women comes to a dramatic, unexpected conclusion in this final volume.