Deep in the California woods on an evening in late August, Jane Pearson is camping with her husband Leo and their five-year-old son Benjamin. As dusk sets in, she drifts softly to sleep in a hammock strung outside the tent where Leo and Benjamin are preparing for bed. At that moment, every single person with a Y chromosome vanishes around the world, disappearing from operating theaters mid-surgery, from behind the wheels of cars, from arguments and acts of love. Children, adults, even fetuses are gone in an instant. Leo and Benjamin are gone. No one knows why, how, or where. After the Disappearance, Jane forces herself to enter a world she barely recognizes, one where women must create new ways of living while coping with devastating grief. As people come together to rebuild depopulated industries and distribute scarce resources, Jane focuses on reuniting with an old college girlfriend, Evangelyne Moreau, leader of the Commensalist Party of America, a rising political force in this new world. Meanwhile, strange video footage called "The Men" is being broadcast online showing images of the vanished men marching through barren, otherworldly landscapes. Is this just a hoax, or could it hold the key to the Disappearance?