Earl 'Trey' Singleton III leaves his overbearing parents and their expectations behind by running away to New York City with only a few dollars in his pocket. In the City, Trey meets up with a cast of characters that change his life forever--from civil rights leader Bayard Rustin, who he meets in a Harlem bathhouse, to his landlord, Fred Trump, who he clashes with and outfoxes. He volunteers at a renegade home hospice for AIDS patients, and after being put to the test by gay rights activist Larry Kramer and civil rights leader Dorothy Cotton, becomes a founding member of the AIDS Coalition to Unleash Power (ACT UP). Along the way Trey attempts to navigate past traumas and searches for ways to maintain familial relationships--all while seeking the meaning of life in the midst of so much death.