Education is the new buffalo" is a metaphor widely used among Indigenous peoples in Canada to signify the importance of education to their survival and ability to support themselves, as once Plains nations supported themselves as buffalo peoples. The assumption is that many of the pre-Contact ways of living are forever gone, so adaptation is necessary. But Chelsea Vowel asks, "Instead of accepting that the buffalo, and our ancestral ways, will never come back, what if we simply ensure that they do?" Inspired by classic and contemporary speculative fiction, Buffalo Is the New Buffalo explores science fiction tropes through a MÔetis lens: a Two-Spirit rougarou (shapeshifter) in the nineteenth century tries to solve a murder in her community and joins the nÒehiyaw-pwat (Iron Confederacy) in order to successfully stop Canadian colonial expansion into the West. A MÔetis man is gored by a radioactive bison, gaining super strength, but losing the ability to be remembered by anyone not related to him by blood. Nanites babble to babies in Cree, virtual reality teaches transformation, foxes take human form and wreak havoc on hearts, buffalo roam free, and beings grapple with the thorny problem of healing from colonialism.