Wanting a fresh start after a broken relationship and a stressful job in the UK, Dr. Ruby Walker takes a job in India. Although she applied to work at a new urban clinic, Ruby ends up at the overcrowded and underfunded Good Karma Hospital run by the formidable Dr. Lydia Fonseca. As she adjusts to her new life in rural india, Ruby slowly realizes that the hospital may be more than the rundown medical outpost it appears to be.