The story follows the journey of James Cole, a man from 2043 sent back in time to stop a malevolent organization known as the Army of the 12 Monkeys from destroying the world. Joining forces with Dr. Cassandra Railly in the present day, Cole must untangle a conspiracy that's been spun throughout centuries. As Cole, Dr. Railly and their unlikely allies get closer to discovering the truth they will learn that there are not only deadly consequence for mankind, but time itself.