An adaptation of Arturo Perez-Revertes best selling novel La Reina Del Sur tells the story of Teresa Mendoza, who after her drug-dealing boyfriend is unexpectedly murdered in Mexico, is forced to go on the run and seek refuge in America. There, she teams with an unlikely figure from her past to bring down the leader of the same drug trafficking ring that has her on the run. In the process, she learns the tools of the trade and strategically positions herself to become the leader of the cartel.