The plot revolves around a new drug that has been unleashed on the streets of New York: Triple X, a form of ecstasy that has been irradiated with gamma radiation (the same stuff that turned Bruce Banner into the Hulk), so it not only gets you high, it temporarily gives you super powers. Spidey and the NYPD have to find out who's responsible for the drug, stop the rampaging "gamma-heads," and also keep the lid on a drug war that's breaking out, since the new drug is cutting into the profits of those that distribute other illicit substances, and the latter are expressing their displeasure with guns.