Eminent psychiatrist Frasier Crane leaves Boston to start life afresh in Seattle and finds himself on the radio airwaves as the host of his own call-in advice show. When he's not dealing with problems of his troubled listeners, he's embroiled in skirmishes at home involving Marty, his retired police detective father; Daphne, his father's physical therapist; his younger brother (and rival) Niles, and Eddie ... his father's devious dog.