After accidentally learning of a planned assassination attempt on the life of President Ulysses S. Grant, Breanna risks her own safety to protect the country's leader. Afterward, she is invited to Washington to receive a commendation before Congress, and on the way home the traveling nurse comes across an "orphan train" carrying children out West to find adoptive families. A special bond forms between Breanna and three of the children who she leads to the Lord. But when the children's new family is not all that it appears, Breanna is called upon to once more help the three precious ones in Suffer the Little Children.