Mma "Precious" Ramotswe sets up a detective agency in Botswana on the edge of the Kalahari Desert, making her the only female detective in the country. At first, cases are hard to come by. But eventually, troubled people come to Precious with a variety of concerns. Potentially philandering husbands, seemingly schizophrenic doctors, and a missing boy who may have been killed by witch doctors all compel Precious to roam about in her tiny van, searching for clues.