1910: people are mysteriously dying at an alarming rate in the Russian-ruled city of Kharbin, a major railway outpost in Northern China. Strangely, some of the dead bodies vanish before they can be identified. During a dangerously cold winter in a city gripped by fear, the Baron, a wealthy Russian aristocrat and the city's medical commissioner, is determined to stop this mysterious plague. Battling local customs, an occupying army, and a brutal epidemic with no name, the Baron is torn between duty and compassion, between Western medical science and respect for Chinese tradition. His allies include a French doctor, a black marketeer, and a charismatic Chinese dwarf. His greatest refuge is the intimacy he shares with his young Chinese wife -- but she has secrets of her own.