Slade Steadman, a writer who has lost his chops, sets out for the Ecuadorian jungle with his ex-girlfriend in search of inspiration and a rare hallucinogen. The drug, once found, heightens both his powers of perception and his libido, but it also leaves him with an unfortunate side effect: periodic blindness. Unable to resist the insights that enable him to write again, Steadman spends the next year of his life in thrall to his psychedelic muse and his erotic fantasies, with consequences that are both ecstatic and disastrous.