Isabel is asked to help a doctor who has been disgraced by allegations of scientific fraud concerning a newly marketed drug. Our ever-curious moral philosopher finds her interest piqued. Would a doctor with a stellar reputation make such a simple but grave mistake? If not, what explains the tragic accident that resulted in the death of a patient? Clearly, an investigation is in order, especially since a man's reputation is in jeopardy. Could he be the victim of someone else's mistake? Or perhaps he has been willfully deceived by a pharmaceutical company with a great deal to gain. Not every problem prompts an investigation (take, for example, her ongoing struggle with her housekeeper, Grace, over the care of Isabel's infant son, Charlie), but, as we've seen, whatever the case, whatever the solution, Isabel's combination of spirit, smarts, empathy, and unabashed nosiness guarantees a delightful adventure.