Spanning eras and generations, this story tells of the lives of three unforgettable women: Miss May Belle, a wise healing woman; her precocious and observant daughter Rue, who is reluctant to follow in her mother's footsteps as a midwife; and their master's daughter Varina. The secrets and bonds among these women and their community come to a head at the beginning of a war and at the birth of an accursed child, who sets the townspeople alight with fear and a spreading superstition that threatens their newly won, tenuous freedom.