In the near future, in the hills of the American Northeast, a group of men, women, and children band together for survival against nature and human enemies, huddling in the only corner of the world they know. Among these people is Janie Crowe, a physician whose son is her greatest hope and deepest secret. Etched into Janie’s memory is the ancient journal of a Jewish man of medicine–a man who fought for survival in his own age of plague.