When the plague visits an isolated village in the English countryside, a housemaid named Anna Frith emerges as an unlikely heroine and healer. Through Anna's eyes we follow the story of the fateful year of 1666, as she and her fellow villagers endure a self-imposed quarantine to keep the disease from spreading. As death reaches into every household and villagers turn from prayers to murderous witch-hunting, Anna must find the strength to confront the disintegration of her community and the lure of illicit love. As she struggle to survive and grow, a year of catastrophe becomes instead annus mirabilis, a "year of wonders".