F.B.I. Agent Seeley Booth, teams up with forensic anthropologist Dr. Temperance 'Bone' Brennan to solve some of the most baffling and bizarre crimes ever. Booth depends on clues from the living, witnesses, and suspects, while Brennan gathers evidence from the dead, relying on her uncanny ability to read clues left behind in the bones of the victims. Their different investigative styles cause the two to frequently clash, creating an undeniable chemistry and just the right touch of dark humor.