When the dearly departed Doctor Strange sends a dire warning from beyond the grave, America Chavez, the Blue Marvel, Tigra and Loki assemble alongside Taaia--mother of Galactus--to defend reality itself! Their incredible journey takes them all the way back to the Second Cosmos, where their lives lie in the hands of its almighty overseers--unless Loki can figure out the right trick to save them all! But not everybody will make it out unscathed.