Chief amongst GrÔainne's plots: to encrypt cataclysmic spells into Shakespeare's "cursed" play, Macbeth. When her fellow rogue agents fall victim to GrÔainne's schemes, Melisande Stokes is forced to send Tristan's untested, wayward sister Robin back in time to 1606 London, where Edmund Tilney, the king's Master of Revels, controls all staged performances in London. And now GrÔainne controls Tilney. While Robin poses as an apprentice in Shakespeare's Globe Theatre, Mel travels to the ancient Roman Empire and, with the help of double-agent Chira in Renaissance Florence, untangles the knotted threads of history while the diabolical GrÔainne jumps from timeline to timeline, always staying frustratingly one stop ahead—or is it behind? Historical objects disappear, cities literally rise and fall, and nothing less than the fate of humanity is at stake. As GrÔainne sows chaos across time and space, the ragtag team of ex-D.O.D.O. agents must fix the past—in order to save the future.