Under contract with A.I.M., Deadpool ventures into the Savage Land to obtain the ultimate biological weapon - his own dang head! Yup, Zombie Deadpool's decapitated head makes its glorious return, and he's tired of being carried around everywhere. Deadpool will have to keep his own head on straight if he hopes to survive these Savage Land shenanigans and collect his bounty. Then, as if the zombie thing wasn't enough, it's alternate universe mayhem as Deadpool encounters a multitude of malevolent mirror images: S.H.I.E.L.D Major Wilson, Wanda Wilson and the Deadpool Kid. But what happens when Deadpool, A.I.M. agents and his foxy new ladylove travel into the Marvel Zombieverse to try to return "Headpool" home?