Rome, 1520. The Eternal City is in mourning. Raphael Sanzio, beloved painter and national hero, has died suddenly at the height of his fame. His body lies in state at the splendid marble Pantheon. At the nearby convent of Sant'Apollonia, a young woman comes to the Mother Superior, seeking refuge. She is Margherita Luti, a baker's daughter from a humble neighborhood on the Tiber, now an outcast from Roman society, persecuted by powerful enemies within the Vatican. Margherita was Raphael's beloved and appeared as the Madonna in many of his paintings. Theirs was a love for the ages. But now that Raphael is gone, the convent is her only hope of finding an honest and peaceful life.