Larry, Moe and Curly Joe work for an editor at a Boston wildlife conservation magazine. They make such a mess of the pressroom that their publisher gets rid of them by sending them out West to stop the slaughter of buffalo. Upon their arrival they find themselves being sought after by every notorious gunslinger in history.

Goofs and saddles: Moe Howard, Larry Fine and Curly Howard are enlisted by Civil War General Muster to help save the country from a notorious cattle rustler.