General Cain orders The Hive reopened, and in doing so contaminates all of Raccoon City, a city of the dead, with Alice stuck right in the middle. Now, along with other surviors, Jill, Carlos and Captain Nicholai, they must fight to survive and escape the nightmare that has plaqed Raccoon City. Matt Addison has become a new threat as he has fully mutated into a seemingly unstoppable creature, code named Nemesis. Nemesis will stop at nothing until everything around him is dead.