From the director of the Mayo Clinic/Arizona State University Obesity Solutions Initiative, and inventor of the treadmill desk, a fascinating wake-up call about our sedentary lifestyle. That the average adult spends 50 to 70 percent of their day sitting is no surprise to anyone who works in an office. But few realize the health consequences they are suffering as a result of their sedentary lifestyle. Today's chair-based world, where we no longer use our bodies as they evolved to be used, is having negative consequences on our health, and is a leading cause of diabetes, cancer, and heart disease. Over the decades, humans have moved from a primarily active lifestyle to one that is largely sedentary, and this change has reshaped every facet of our lives--from social interaction to classroom design. Throw off the shackles of inertia and reverse these negative trends through simple changes in your daily routine.