Aaron Cordic and Samantha Riske are a couple of twenty-something hypochondriacs living in east-end Toronto. While Aaron works part-time at a bathroom supply store, Samantha hides herself away in their apartment, tip-toeing around naked and spying on the neighbours. Between paranoid trips to the doctor and extremely intimate examinations of each other's bodies, they've managed to eke out an isolated and highly sterilized existence. Then, one day, birds begin falling from the sky as numerous tenants in their building become mysteriously ill. Before long, a pandemic known as Buzzard Flu has swept across the city, and Aaron and Samantha must come to terms with the all-too-real possibility that disease, or even death, could finally be at hand. But is Buzzard Flu the biggest problem the couple must face? Or does a more dangerous killer lurk closer to home.