Milan, 1492: When a sixteen-year old beauty becomes the mistress of the Duke of Milan, she must fight for her place in the palace, and against those who want her out. Soon, she finds herself sitting before Leonardo da Vinci, who wants to ensure his own place in the ducal palace by painting his most ambitious portrait to date. Munich, World War II: After a modest conservator unwittingly places a priceless Italian Renaissance portrait into the hands of a high-ranking Nazi leader, she risks her life to recover it, working with an American soldier, part of the famed Monuments Men team, to get it back. Two women, separated by 500 years, are swept up in the tide of history as one painting stands at the center of their quests for their own destinies