In 2003, a parasitic fungal infection ravages the planet, turning humans into violent creatures known as the Infected. Twenty years later, hardened survivor Joel is hired to smuggle fourteen-year-old Ellie out of an oppressive quarantine zone in hopes of delivering her to the rebel Fireflies. But what should be a quick job soon becomes a brutal and heartbreaking journey as they traverse the desolate U.S. while depending on each other's unique skills for survival.