Kayako and Toshio's curse continues to haunt survivor, Jake. He is now confined to a psychiatric hospital after his family's alleged suicide. When the curse of the Grudge finally kills him too, news reaches a mysterious young woman in Japan. Dr. Sullivan who was Jake's case worker, goes to investigate his Chicago home. In the meantime, the curse continues to claim more victims. As the rage spreads, it becomes clear that Jake's horrifying stories are true, and the Japanese woman is the only hope of finally burying the Grudge once and for all - unless she becomes another victim.