When the two boys uncover a skeletal hand on the beach, they find themselves anxious to solve a mystery. The two friends come of age and begin their professional careers, where they continue their quest for meaning and reach new levels of understanding. As they advance, they collaborate with peers throughout the world who share their same thirst for knowledge. Together, they ponder topics including Adam and Eve in the Garden of Eden, The Origin of Species by Charles Darwin, life on the sea, and much more.