Hannah and Isaac Levi, Venetians in exile, have set up a new life for themselves in Constantinople. Isaac runs a newly established business in the growing silk trade, while Hannah, the best midwife in all of Constantinople, plies her trade within the opulent palace of Sultan Murat III, tending to the thousand women of his lively and infamous harem. But one night, when Hannah is unexpectedly summoned to the palace, she's confronted with Leah, a poor Jewish peasant girl who has been abducted and sold into the sultan's harem.