Spanning generations, River of the Brokenhearted tells the life and legacy of Janie McCleary, a strong-willed Irish Catholic girl who dares to marry a man from the Church of England. Their union is quickly deemed scandalous, and when her husband dies young, just before the Great Depression, Janie is left alone to raise a family and run a business - the first movie theater in town. Through the strength of her character, she succeeds in a world of men. For that she is ostracized and becomes a victim of double-dealing and overt violence. Based on the author's own grandmother, Janie is a pioneer before the age of feminism, but her salty individualism burdens the lives of her children and grandchildren. Her son Miles, impish and genteel, tragically misunderstood and quietly courageous, is bullied and bruised by those his age, and unable to escape his mother's shadow. When sorrow befalls the family he retreats into eccentricity and alcoholism. The specter of Janie is raised again in her granddaughter Ginger - brilliant, funny, tempestuous, as fiery in spirit as Janie ever was. But moving without her grandmother's sure-footedness through an equally treacherous world. Ginger forms an alliance with the one person most likely to destroy her.