Ambrose Zephyr and his wife Zappora Ashkenazi (“Zipper”) have achieved a happy and balanced life together. She is the yin to his yang. He is the only man she has loved without adjustment. The two live contentedly in a narrow London terrace full of books. That contentment is thrown into turmoil on or about Ambrose’s fiftieth birthday, when they receive the news that he has contracted a mysterious illness that will most certainly lead to his death within the month. In panicked delirium, from beneath their bed Ambrose withdraws an oxblood suitcase containing the ephemera of his long-suppressed life’s ambition: to travel the world in a pilgrimage through the alphabet, from Amsterdam to Zanzibar.