What's better than a family at heart? Recently single, Francesca Thayer fears having to part with her art gallery and her charming house in Greenwich Village. A solution is needed to save your finances: shared accommodation! Slowly, 44 Charles Street is coming back to life. First with Eileen, a young special education teacher, then with Chris, a divorced father, and finally with Marya, a famous cook who has just lost her husband. A joyful bond develops between the roommates and, carried by this new energy, Francesca feels ready to open her heart again. But life sometimes has its share of unpleasant surprises and, when tragedy strikes, everyone must soon stick together like a real family...