Dr. Kate Philo and her scientific exploration team make a breathtaking discovery in the Arctic: the body of a man buried deep in the ice. As a scientist in a groundbreaking project run by the egocentric and paranoid Erastus Carthage, Kate has brought small creatures "back to life." Never have the team's methods been attempted on a large life form. Heedless of the consequences, Carthage orders that the frozen man be brought back to the lab in Boston, and reanimated.