Add a little bit of Spidey and a touch of Deadpool, take away the Y chromosomes, blend it all together, and what do you get? Peter Parker and Wade Wilson's worst nightmare: the murderous, mixed-up miss named Itsy Bitsy! The "daughter" of our two heroes is stronger than them, faster than them and has seriously creepy daddy issues -- but what crazed mind could have conceived of her in the first place? As the body count rises, Spider-Man and Deadpool must work together to take down Itsy Bitsy -- and the person who's been pulling their strings from the start! But how is a trip to Weirdworld going to help wash that spider out? It's the most disturbing Spidey/Deadpool story yet, from the wild imagination of Joe Kelly and Ed McGuinness!