A charming London neighborhood is home to Roger and Anita, whose beloved dalmatians, Pongo and Perdita, have become the proud parents of 15 puppies. But when Cruella DeVille and her henchmen appear, the pups soon disappear, along with every other Dalmatian puppy in town. Now Pongo and Perdita must rally their animal friends and use the power of the "Twilight bark" to find Cruella's secret hideaway and free the puppies.