Nine human beings from across the globe are remodeled against their wills into human weapons known as Cyborgs by the nefarious Black Ghost Organization. Our hero, 009, is half-Japanese, half-American and, equipped with Mach-speed acceleration among other extraordinary abilities, is the most advanced of the nine Zero-Zero Cyborgs (all of whom have super powers). From different countries, different races and even different eras, theses nine inimitable individuals cooperate with each other to fight agains Black Ghost and the strange vicissitudes of their fortunes.