He's sarcastic, incorrigible, bitter, and in a relationship? Dr. Gregory House has spent his career taking on seemingly hopeless cases, but when his rapport with Dr. Lisa Cuddy changes, he finds himself facing new, and very different, challenges. His team at Princeton-Plainsboro Teaching Hospital also continues to blaze trails as they investigate baffling medical cases involving a religious zealot, a professional bull rider, and possibly even smallpox.