Fearless documentary filmmaker Laura Poitras's career-long pursuit of truth and justice finds powerful expression in an epic story of art, activism, and survival. Made in collaboration with renowned artist Nan Goldin, All the Beauty and the Bloodshed entwines the mission of PAIN an advocacy group she founded to raise awareness about the billionaire Sackler family's integral role in the ongoing crisis of opioid overdoses with an intimate journey through Goldin's life, from her rebellious adolescence and immersion in New York City's thriving underground arts scene to her personal experiences of addiction and the AIDS epidemic. Through it all, her indelible photographs and candid reflections on memory and trauma reveal her unyielding solidarity with marginalized communities that refuse to remain silent.